How can I make an item spend other items when using it?

In the player procedures tab there is a block called Remove (1) (item type) from (Event/target entity) main inventory. By replacing the 1 with any number you can remove as many as a specific type of item from an entity's inventory. You can also get rid of items from the player's main-hand/off-hand by combining the Shrink (Provided itemstack) for (1) block found in the item procedures with the Item in main/off-hand of (Event/target entity) block found in the player procedures tab.